Philipp Wild

Preventive Cardiology and Preventive Medicine

Our team is dedicated to studying common, complex ageing-related diseases that impose a high burden on society, in particular cardiovascular disease. Using an integrated systems medicine approach, we aim to achieve a deep understanding of clinical and subclinical pheno- and endotypes. We do this by characterising and analysing disease at all stages – from before clinically-established disease (subclinical stage), through to its development, progression and sequelae or cure. Our holistic approach reflects all levels that influence disease. This includes deep phenotyping of the individual and his/her environment, using sequential multi-omics data, advanced medical-technical examinations including organ-level imaging and a thorough inventory of their lifestyle, social situation and other environmental exposures.

To achieve these goals, we design and conduct prospective population and clinical studies, thereby establishing large biodatabases such as the Gutenberg Health Study. The data are analysed by a multidisciplinary team covering expertise in clinical (bio)medicine, molecular biology and biochemistry, bioinformatics and statistics/AI. The insights obtained are leveraged to identify novel therapeutic targets and to develop diagnostic and prognostic applications, as well as monitoring therapies.

Research website

Gutenberg Health Study

Positions held

• Since 2022: Principal Investigator in Systems Medicine (Adjunct Clinician), Institute of Molecular Biology (IMB)
• Since 2020: Deputy Site Speaker for Rhein-Main, German Center for Cardiovascular Research (DZHK)
• Since 2015: Board Member, Scientific Medical Research Centre (NMFZ), University Medical Center (UMC), Mainz
• Since 2015: Head of Liquid Biobank, University Medical Center (UMC), Mainz
• Since 2015: Speaker, Research Center for Translational Vascular Biology (CTVB), University Medical Center (UMC), Mainz
• Since 2014: Member of the Steering Board of the Mainz Research School of Translational Biomedicine (TransMed), University Medical Center (UMC), Mainz
• Since 2014: W3-Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis Mainz (CTH), University Medical Center (UMC), Mainz
• Since 2013: Head of Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center (UMC), Mainz
• Since 2012: Head of “Clinical Epidemiology and Systems Medicine”, Center for Thrombosis and Hemostasis (CTH), University Medical Center (UMC), Mainz
• 2012 - 2014: W2-Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis (CTH), University Medical Center (UMC), Mainz
• Since 2011: Coordinating Principal Investigator and Steering Committee Member of the Gutenberg Health Study (GHS), University Medical Center (UMC), Mainz
• 2010 - 2012: Senior Physician, Dept. of Medicine 2, University Medical Center (UMC), Mainz

Education

• 2022: Specialist in Internal Medicine and Cardiology
• 2012: Master of Science in Epidemiology (MSc) IMBEI, University Medical Center (UMC), Mainz 
• 2009: Specialist in Internal Medicine
• 2004: MD, Philipps University Marburg (summa cum laude)
• 1996 - 2002: Medical School, University Leipzig and Medical School, Philipps University Marburg

Selected publications by Philipp Wild

Tröbs SO*, Prochaska JH*, Schwuchow-Thonke S, Schulz A, Müller F, Heidorn MW, Göbel S, Diestelmeier S, Lerma Monteverde J, Lackner KJ, Gori T, Münzel T and Wild PS (2021) Association of global longitudinal strain with clinical status and mortality in patients with chronic heart failure. JAMA Cardiol, 6:448–456 Link

Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T and Wild PS (2021) Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. Eur Heart J, 42:4157–4165 Link

Ten Cate V, Prochaska JH, Schulz A, Koeck T, Pallares Robles A, Lenz M, Eggebrecht L, Rapp S, Panova-Noeva M, Ghofrani HA, Meyer FJ, Espinola-Klein C, Lackner KJ, Michal M, Schuster AK, Strauch K, Zink AM, Laux V, Heitmeier S, Konstantinides SV, Münzel T, Andrade-Navarro MA, Leineweber K and Wild PS (2021) Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism. Blood, 137:2681–2693 Link

Neumann JT, Twerenbold R, […], Wild PS, […] and Blankenberg S (2019) Application of high-sensitivity troponin in suspected myocardial infarction. N Engl J Med, 380:2529–2540 Link

Wild PS, Felix JF, Schillert A, […], Vasan RS and Dörr M (2017) Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest, 127:1798–1812 Link