Philipp Wild

Preventive Cardiology and Preventive Medicine

Our team is dedicated to studying common, complex ageing-related diseases that impose a high burden on society, in particular cardiovascular disease. Using an integrated systems medicine approach, we aim to achieve a deep understanding of clinical and subclinical pheno- and endotypes. We do this by characterising and analysing disease at all stages – from before clinically-established disease (subclinical stage), through to its development, progression and sequelae or cure. Our holistic approach reflects all levels that influence disease. This includes deep phenotyping of the individual and his/her environment, using sequential multi-omics data, advanced medical-technical examinations including organ-level imaging and a thorough inventory of their lifestyle, social situation and other environmental exposures.

To achieve these goals, we design and conduct prospective population and clinical studies, thereby establishing large biodatabases such as the Gutenberg Health Study. The data are analysed by a multidisciplinary team covering expertise in clinical (bio)medicine, molecular biology and biochemistry, bioinformatics and statistics/AI. The insights obtained are leveraged to identify novel therapeutic targets and to develop diagnostic and prognostic applications, as well as monitoring therapies.

Research website

Gutenberg Health Study

Positions held

• Since 2024: Researcher, German Cancer Consortium (DKTK)
• Since 2022: Board Member of the Mainzer Herz Foundation
• Since 2022: Adjunct Clinician, Institute of Molecular Biology (IMB)
• Since 2020: Deputy Site Speaker for Rhein-Main, German Center for Cardiovascular Research (DZHK)
• Since 2015: Board Member, Scientific Medical Research Centre (NMFZ), University Medical Center (UMC), Mainz
• Since 2015: Head of Liquid Biobank, University Medical Center (UMC), Mainz
• Since 2015: Speaker, Research Center for Translational Vascular Biology (CTVB), University Medical Center (UMC), Mainz
• Since 2014: Member of the Steering Board of the Mainz Research School of Translational Biomedicine (TransMed), University Medical Center (UMC), Mainz
• Since 2014: W3 Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis Mainz (CTH), University Medical Center (UMC), Mainz
• Since 2013: Head of Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center (UMC), Mainz
• Since 2012: Head of “Clinical Epidemiology and Systems Medicine”, Center for Thrombosis and Hemostasis (CTH), University Medical Center (UMC), Mainz
• 2012 - 2014: W2 Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis (CTH), University Medical Center (UMC), Mainz
• Since 2011: Coordinating Principal Investigator and Steering Committee Member of the Gutenberg Health Study (GHS), University Medical Center (UMC), Mainz
• 2010 - 2012: Senior Physician, Dept. of Medicine 2, University Medical Center (UMC), Mainz

Education

• 2022: Specialist in Internal Medicine and Cardiology
• 2019: Clinical Trial Management (CTM)
• 2012: Master of Science in Epidemiology (MSc) IMBEI, University Medical Center (UMC), Mainz
• 2009: Specialist in Internal Medicine
• 2004: MD, Philipps University Marburg (summa cum laude)
• 1996 - 2002: Medical School, University Leipzig and Medical School, Philipps University Marburg

Selected publications by Philipp Wild

Wild PS and Zeller T (2025) From locus to lipase: LIPA as a paradigm for post-GWAS mechanistic and translational research in CAD. Eur Heart J, 46:5289-5291 Link

Baumkötter R, Yilmaz S, Chalabi J, Ten Cate V, Mamoor Alam AS, Golriz Khatami S, Zahn D, Hettich-Damm N, Prochaska JH, Schmidtmann I, Lehnert K, Steinmetz A, Dörr M, Pfeiffer N, Münzel T, Lackner KJ, Beutel ME and Wild PS (2025) Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population. Eur J Epidemiol, 40:789-801 Link

Panova-Noeva M, Koeck T, Schoelch C, Schulz A, Prochaska JH, Michal M, Strauch K, Schuster AK, Lackner KJ, Münzel T, Hennige AM and Wild PS (2024) Obesity-related inflammatory protein signature in cardiovascular clinical outcomes: Results from the Gutenberg Health Study. Obesity, 32:1198–1209 Link

Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV and Wild PS (2023) Circulating microRNAs predict recurrence and death following venous thromboembolism. J Thromb Haemost, 21:2797-2810 Link

Krolevets M, Cate VT, Prochaska JH, Schulz A, Rapp S, Tenzer S, Andrade-Navarro MA, Horvath S, Niehrs C and Wild PS (2023) DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites. Clin Epigenetics, 15:56 Link