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1. Hallmark of ageing: Disrupted gene regulation  
Epigenetic markers control gene activity  The blueprints for all the proteins that keep our cells running are stored in the DNA. To make the DNA fit in the cell nucleus, it is wrapped around…  
2. Hallmark of ageing: Loss of protein maintenance & reduced cell recycling  
Impaired proteostasis and autophagy are two closely linked primary hallmarks of ageing. Autophagy is the process by which cells break down and recycle their components.Cellular waste disposal …  
3. What causes ageing: the "Hallmarks of ageing"  
Ageing is caused by only five biological processes Although ageing has been linked to a host of diseases, scientists have surprisingly found that ageing itself is caused by only five core molecular…  
4. Healthy ageing is possible  
Record holders for long life For humans, the longest recorded lifespan is 122 years and 164 days. This record is held by Jeanne Calment, a French supercentenarian who was born in 1875 and passed…  
5. Curing age-related diseases and prolonging life?  
We often suffer from several age-related diseases at once Let's assume that we could completely cure cardiovascular diseases, which kill more than one in three people. Shouldn't life expectancy…  
6. Ageing Explained  
This website is for general informational and educational purposes only. We take every effort to ensure that the information published is accurate and supported by the current scientific literature…  
7. Why ageing research?  
Today, many countries have more elderly people than ever before. In Germany alone, 23% of the population is over 65, and this is projected to rise in the future. We still do not fully understand…  
8. What happens when we age  
Our risk of dying sharply increases As we age, we accumulate illnesses and our body's ability to regenerate decreases. One way to measure ageing is our risk of dying within a given year. When we are…  
9. Hallmark of ageing: Damage to the DNA  
Our genetic material is constantly at risk The DNA in each of our cells is damaged around 100,000 times every day. That's an average of more than once per second! Since we are made up of over 1013…  
10. Hallmark of ageing: Telomere shortening  
Protection for the ends of our genetic material Each of us begins life as a single cell, which grows to form an entire organism. This process requires many, many cell divisions to produce the…  
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