The central goal of this SFB is to elucidate the molecular mechanisms that modulate the activities of genome maintenance pathways in the cell.
The network brings together experts in structural biology, organic chemistry, biochemistry, molecular and cell biology as well as genetic toxicology and clinical sciences. It makes use of state-of-the-art tools in microscopy, proteomics, genomics, damage detection and quantification as well as a wide panel of DNA repair assays. By focussing on the fundamental regulatory mechanisms of the DNA damage response, we will obtain insight into how the different repair and genome maintenance pathways manage to maintain a balance between cell death and survival, genome stability and plasticity, and gene regulation.
Regulation of genome stability and DNA repair is central to understanding the mechanisms underlying ageing, as the majority of mutations that lead to premature ageing and degeneration occur in genes involved in DNA repair.
The SFB 1361 is funded by the DFG from 2019 - 2022.
For more information on the SFB 1361, please visit www.sfb1361.de.