Phase Separation in Homeostasis & Age-Related Diseases
We want to elucidate how phase separation of proteins can be a regulatory mechanism of resilience and how dysregulation of phase separation…
Lipid Homeostasis in Ageing & Longevity
Ageing is characterised by a gradual decline of tissue function. But age progression can be slowed by interventions such as diet. For example, diets rich in…
Eco-evolutionary & Life History Modelling of Ageing
Nature shows an amazing diversity of life-history strategies, i.e. the scheduling of important events in an organism’s life cycle: within the same…
DNA Double-Strand Breaks & Genomic Instability
The integrity of the DNA in our cells is essential for normal cellular functions. However, DNA damage, caused by various endogenous and exogenous…
Ageing, Monocytes, Interferon & Thrombosis
In our laboratory, we focus on how ageing, interferon signalling and monocyte biology come together to influence the development of thrombosis. As we…
Evolutionary Play in Gene Expression
Gene expression is fundamental to life, converting the information in DNA into proteins. Throughout evolution, cells have developed a rich variety of mechanisms…
Translational Regulation
Post-transcriptional gene regulation is essential for many biological processes. During ageing, mRNA and protein levels become progressively decoupled, implicating…
