Immune mechanisms of chronic skin diseases in ageing
Dendritic cells are crucial for initiating adaptive immune responses, which are often linked to chronicity and disease severity. We found that…
The process of healthy ageing requires a functional immune system both in peripheral blood and in the brain. Chronic inflammatory diseases driving premature immunosenescence are valuable models for…
Cardiovascular ageing – the role of telomere shortening, inflammation and reactive oxygen species (ROS)
We are facing dramatically rising numbers of patients of increasing age. Efforts and costs are…
Compelling evidence points to the gut as a starting point for neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. Enteric glia cells (EGC) are key players in the maintenance of…
The role of PAR-2 signalling in cardiac ageing and inflammation in heart failure
Ageing is a major risk factor for cardiovascular diseases, reflecting the most important cause of morbidity and…
Improving Cancer Immunotherapies
Cancer immunotherapies have revolutionised treatments for patients with relapsed and refractory malignant disease. However, many patients do not respond or…
