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Katrin Pape

Unravelling the role of cellular immunosenescence for the inflammaging brain

The process of healthy ageing requires a functional immune system both in peripheral blood and in the brain. Chronic inflammatory diseases driving premature immunosenescence are valuable models for studying age-associated immune dysfunction and its effects on brain reserve. Using cerebrospinal fluid (CSF) samples obtained from the clinic, we aim to investigate different molecular levels of immunosenescence pathways using a multi-omics approach to healthy ageing, neuroinflammation and neurodegeneration.

Positions held

  • Since 2023: Clinician Scientist funded by CHANCE, Department of Neurology, University Medical Center (UMC) and Institute of Molecular Biology (IMB), Mainz
  • Since 2023: Medical mentoring programme, University Medical Center Mainz (MeMentUM)
  • 2022 - 2023: Residency at the Department of Psychiatry, University Medical Center Mainz
  • Since 2016: Residency at the Department of Neurology, University Medical Center Mainz


  • 2015: MD, Medical Center - University of Freiburg
  • 2008 - 2016: Medical Studies, Medical Center - University of Freiburg and Gothenburg, Sweden (supported by the Studienstiftung des deutschen Volkes)

Selected publications by Katrin Pape

Bittner S, Pape K, Klotz L and Zipp F(2023) Implications of immunometabolism for smouldering MS pathology and therapy.Nat Rev Neurol, 19:477–488 Link

Schuckmann A, Steffen F, Zipp F, Bittner S and Pape K (2023) Impact of extended interval dosing of ocrelizumab on immunoglobulin levels in multiple sclerosis.Med, 4:361–372.e3 Link

Pape K, Rolfes L, Steffen F, Muthuraman M, Korsen M, Meuth SG, Zipp F and Bittner S (2022) Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score-matched study.Ther Adv Neurol Disord, 15:1–15 Link

Eschborn M, Pawlitzki M, Wirth T, Nelke C, Pfeuffer S, Schulte-Mecklenbeck A, Lohmann L, Rolfes L, Pape K, Eveslage E, Bittner S, Gross CC, Ruck T, Wiendl H, Meuth SG and Klotz L (2021) Evaluation of age-dependent immune signatures in patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm, 8(6):e1094  Link