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Stephan Grabbe

Skin Immunology & Immunotherapy of Skin Tumours

Our main area of interest is immunological research, specifically:

  • Immunotherapy using functionalised nanoparticles, and
  • Understanding the significance of beta-2 integrins for leukocyte function 

We also perform translational research and clinical studies on the following topics:

  • Mechanisms of immunotherapy and tumour resistance in malignant melanoma
  • Immunotherapy with functionalised nanoparticles
  • Analysing the local immune response in solid tumours

Research website

Positions held

  • Since 2007: Director (W3), Dept. of Dermatology, University Medical Center (UMC), Mainz
  • 2003 - 2007: Director (C4), Dept. of Dermatology, University of Essen Medical Center 
  • 2000 - 2003: Professor (C3) for Dermatology and Dermato-Oncology, University of Münster 
  • 1998 - 1999: Heisenberg scholarship: Visiting Scientist at the “Skin Disease Research Center“, Brigham and Womens’ Hospital, Harvard University, Boston 
  • 1992 - 1998: Research associate, later ‘University Assistant’ (C1), ‘Senior University Assistant’ (C2), Dept. of Dermatology, University of Münster 
  • 1989 - 1992: Postdoctoral Research Fellow, Wellman Laboratories of Photomedicine and MGH-Harvard Cutaneous Biology Research Center, Mass. General Hospital, Harvard University, Boston 
  • 1987 - 1989: Research associate, Dept. of Dermatology, University of Münster

Education

  • 1996: Habilitation, University of Münster
  • 1995 - 1996: Dermatology, Allergology & Phlebology National Boards (Germany) 
  • 1987: Doctoral degree in human medicine, University of Münster
  • 1980 - 1987: Human medicine, University of Münster

Selected publications by Stephan Grabbe

Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinckhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C and Türeci Ö (2020) An RNA vaccine drives anti-tumor immunity in patients with checkpoint-inhibition experienced melanoma. Nature, 585:107–112 Link

Liu D, Schilling B, Liu D, Sucker A, Livingstone E, Jerby-Amon L, Zimmer L, Gutzmer R, Satzger I, Loquai C, Grabbe S, Vokes N, Margolis CA, Conway J, He MX, Elmarakeby H, Dietlein F, Miao D, Tracy A, Gogas H, Goldinger SM, Utikal J, Blank CU, Rauschenberg R, von Bubnoff D, Krackhardt A, Weide B, Haferkamp S, Kiecker F, Izar B, Garraway L, Regev A, Flaherty K, Paschen A, Van Allen EM and Schadendorf D (2019) Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma. Nat Med, 25:1916–1927 Link

Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Löwer M, Bukur V, Tadmor AD, Luxemburger U, Schrörs B, Omokoko T, Vormehr M, Albrecht C, Paruzynski A, Kuhn AN, Buck J, Heesch S, Schreeb KH, Müller F, Ortseifer I, Vogler I, Godehardt E, Attig S, Rae R, Breitkreuz A, Tolliver C, Suchan M, Martic G, Hohberger A, Sorn P, Diekmann J, Ciesla J, Waksmann O, Brück AK, Witt M, Zillgen M, Rothermel A, Kasemann B, Langer D, Bolte S, Diken M, Kreiter S, Nemecek R, Gebhardt C, Grabbe S, Höller C, Utikal J, Huber C, Loquai C and Türeci Ö (2017) Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature, 547(7662):222–226 Link

Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Hüsemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Türeci Ö and Sahin U (2016) Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature, 534(7607):396–401 Link

Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM and Beissert S (2006) Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med, 12:1372–9 Link