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Christian Behl

Biochemistry of Neurodegeneration & Ageing

The most frequent human neurodegenerative disorders including Alzheimer’s Disease, Parkinson’s Disease and amyotrophic lateral sclerosis are strictly associated with age; to decode the molecular mechanisms underlying neurodegeneration we therefore start by analysing the molecular differences between young and aged neurons. In particular, we focus on cellular protein homeostasis (proteostasis) – its importance being underlined by the occurrence of specific protein aggregates in several age-associated neurodegenerative disorders– as well as on autophagy and adaptive mechanisms neurons employ to compensate and adapt to different forms of cellular stress.

Research website

Positions held

  • Since 2010: Director of the Institute of Pathobiochemistry, University Medical Center (UMC), Mainz
  • Since 2002: Full Professor (C4) of Pathobiochemistry and Chair of the Institute of Pathobiochemistry, Johannes Gutenberg University (JGU), Mainz
  • Since 2016: Vice Speaker of CRC 1177 “Molecular and Functional Characterization of Selective Autophagy” 
  • 2016 - 2019: Vice Speaker of Focus Program Translational Neurosciences (FTN) 
  • 2005 - 2010: Director, Interdisciplinary Centre for Neurosciences, Johannes Gutenberg University (JGU), Mainz 
  • 2003 - 2008: Executive Director, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University (JGU), Mainz
  • 1997 - 2002: Head (C3) of an Independent-Junior-Group of the Max Planck Society, MPI for Psychiatry, Munich
  • 1994 - 1996: Research Scientist, Head of the Steroidpharmacology Group, MPI for Psychiatry, Munich
  • 1992 - 1994: Postdoc, The Salk Institute for Biological Studies, San Diego

Education

  • 1999: Habilitation, Ludwig Maximilian University, Munich
  • 1991: PhD (Dr. rer. nat.), Thesis in Neurobiology, Julius Maximilians University of Wurzburg
  • 1988: Diplom in Biology, Julius Maximilians University of Wurzburg

Selected publications by Christian Behl

Hiebel C, Sturner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Munch C and Behl C# (2020) BAG3 proteomic signature under proteostasis stress. Cells, 9(11):2416 Link

Besemer AS, Maus J, Ax MDA, Stein A, Vo S, Freese C, Nalbach K, von Hilchen C, Pfalzgraf IF, Koziollek-Drechsler I, Silva B, Huesmann H, Boukhallouk F, Florin L, Kern A, Behl C# and Clement AM# (2020) Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis. Cell Mol Life Sci, 78(2):645–660 Link

Bekbulat F, Schmitt D, Feldmann A, Huesmann H, Eimer S, Juretschke T, Beli P, Behl C# and Kern A# (2020) RAB18 loss interferes with lipid droplet catabolism and provokes autophagy network adaptations. J Mol Bio, 432(4):1216–1234 Link

Chakraborty D, Felzen V, Hiebel C, Sturner E, Perumal N, Mani-cam C, Sehn E, Grus F, Wolfrum U and Behl C# (2019) Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol, 24:101181 Link

Weckmann K, Diefenthaler P, Baeken MW, Yusifli K, Turck CW, Asara JM, Behl C and Hajieva P# (2018) Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction. Sci Rep, 8(1):2337 Link

#indicates joint correspondence