David Weber
Novel Targets for Immuno-oncology Approaches
I am interested in understanding disease and ageing associated immunological processes in order to develop novel intervention strategies. Currently my research is focused on identification and characterisation of novel targets for immuno-oncology approaches. This involves target prediction from patient-derived high-throughput sequencing data (overexpressed antigens, structural variants derived fusion neo-antigens), as well as their functional characterisation in-vitro for the envisioned clinical intervention strategy.
Positions held
- Since 2018: Head of Expression and Cell Biology, Translational Oncology (TRON) at University Medical Center (UMC), Mainz
- 2015 - 2018: Scientist in the unit Expression and Cell Biology, Translational Oncology (TRON) at University Medical Center (UMC), Mainz
- 2010 - 2014: Scientist at the department of Developmental Biology, University of Würzburg
- 2009 - 2010: Gap year: work and travel
- 2009: Scientist assistant, Institute of Human Genetics, Newcastle, UK
- 2008 - 2009: MSc Human Genetics, Newcastle University, UK
- 2005 - 2008: BSc Molecular Biotechnology, Dresden University of Technology and Leibniz Institute for Age Research, Jena
Education
- 2014: PhD, Department of Developmental Biology, University of Würzburg
- 2009: MSc in Human Genetics, Newcastle University, UK
- 2008: BSc in Molecular Biotechnology, Dresden University of Technology and Leibniz Institute for Ageing Research, Jena
Selected publications by David Weber
Weber D*, Ibn-Salem J*, Sorn P, Suchan M, Holtsträter C, Lahrmann U, Vogler I, Schmoldt K, Lang F, Schrörs B, Löwer M and Sahin U (2022) Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens. Nat Biotechnol, 40:1276–1284 (*indicates joint contribution) Link
Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, Klein O, Kuna K, Ouchan Y, Wöll S, Christ E, Weber D, Suchan M, Bukur T, Birtel M, Jahndel V, Mroz K, Hobohm K, Kranz L, Diken M, Kühlcke K, Türeci Ö and Sahin U (2020) An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors. Science, 367:446–453 Link
Sethi R, Becker J, Graaf J, Löwer M, Suchan M, Sahin U and Weber D (2020) Integrative analysis of structural variations using short-reads and linked-reads yields highly specific and sensitive predictions. PLoS Comp Biol, 16:e1008397 Link
Sorn P, Holtsträter C, Löwer M, Sahin U and Weber D (2020) ArtiFuse-computational validation of fusion gene detection tools without relying on simulated reads. Bioinformatics, 36:373–379 Link
Weber D, Heisig J, Kneitz S, Wolf E, Eilers M and Gessler M (2015) Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes. J Mol Cell Cardiol, 79:79–88 Link