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Borhane Guezguez

Epigenetic & Signalling Regulators of Cancer Transformation, Immune Escape & Therapy Resistance

Our research program is focused on dissecting how cancer hijacks stem cell processes and immune properties in normal and malignant hematopoiesis (myelodysplasia and myeloid leukemia). Of major interest is the signalling crosstalk between stromal cells, cancer stem cells and immune cells. To address this, we take a multidisciplinary approach grounded in studies using primary human cells, 3D cultures and leukemia mouse models and capitalise on functional screening of epigenetic/metabolic modulators and developing novel imaging techniques.

Using this approach, we aim to identify the molecular regulatory processes that upon dysregulation lead to cancer transformation/relapse, immune escape and therapy resistance. In doing so, we hope to identify critical therapeutic targets that lead toward translational development of novel cellular therapies for cancer treatment and regenerative medicine.

Research website

Positions held

  • Since 2018: Young Group Leader, DKTK Frankfurt/Mainz, University Medical Center (UMC), Mainz 
  • 2014 - 2017: Research Associate, Stem Cell & Cancer Research Institute, McMaster University
  • 2006 - 2014: Postdoctoral Fellow, Stem Cell & Cancer Research Institute, McMaster University

Education

  • 2002 - 2006: PhD, Institute de Biologie Paris-Seine, Sorbonne University Pierre and Marie Curie Campus, Paris
  • 1999 - 2002: Master thesis, Institute de Biologie Paris-Seine

Selected publications by Borhane Guezguez

Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GNHQ, Galetzka D, Guezguez B, Hundemer M, Bourdon JC, Munder M, Theobald M and Echchannaoui H (2021) Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity. J Immunother Cancer9:e001846 Link

Woods K and Guezguez B (2021) Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia. Frontiers Cell Dev Biol, 9:714716 Link

Guezguez B, Almakadi M, Benoit YD, Shapovalova Z, Rahmig S, Fiebig-Comyn M, Casado FL, Tanasijevic B, Bresolin S, Masetti R, Doble BW and Bhatia M (2016) GSK3 deficiencies in hematopoietic stem cells initiate pre-neoplastic state that is predictive of clinical outcomes of human acute leukaemia. Cancer Cell, 29:61–74 Link

Benoit YD*, Guezguez B*, Boyd AL and Bhatia M (2014) Epigenetic modulation of Wnt/Glycogen synthase kinase-3 signaling to target human cancer stem cells. Clinical Cancer Research, 20:5372–5378 (*indicates joint contribution) Link

Guezguez B, Campbell CJV, Boyd AL, Karanu F, Casado FL, Di Cresce C, Collins TJ, Shapovalova Z, Xenocostas A and Bhatia M (2013) Regional localization within the bone marrow influences the functional capacity of human HSCs. Cell Stem Cell, 13:175–89 Link