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Tobias Bopp

Regulation of T Cell Responses in Disease

The major focus of research in my laboratory is the regulation of T cell responses in a context- and tissue-specific manner. Here, we focus particularly on the functional and molecular characterisation of CD4+FOXP3+ regulatory T (TREG) cell and CD4+ T Helper (TH) cell differentiation and function, and on non-classical ways of communication between non-hematopoietic cells and cells of myeloid and lymphoid origin. We aim to elucidate the role of transcription factors and transcription factor complexes in the differentiation and tissue-specific functions of TREG and TH cell subsets in cancer, allergy and autoimmune disease, the role of cyclic AMP-mediated signalling in the regulation of auto-reactive T cell responses, and the role of the kinase CK2 in regulating tissue- and context-specific responses of TH cells and TREG cells.

Research website

Positions held

  • Since 2019: Full Professor (W3) and Chair, IFI, University Medical Center (UMC), Mainz
  • 2012 - 2019 Associate Professor (W2) for “Molecular immunology”, University Medical Center (UMC), Mainz
  • 2008 - 2012 Head of a scientific working group, IFI, University Medical Center (UMC), Mainz
  • 2006 - 2008 Postdoctoral Fellow, IFI, University Medical Center (UMC), Mainz

Education

  • 2003 - 2006: Doctoral thesis (Dr. rer. nat.), IFI, University Medical Center (UMC), Mainz
  • 1997 - 2003: Studies of biology (Diploma), Johannes Gutenberg University (JGU), Mainz

Selected publications by Tobias Bopp

Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A and Probst HC (2020) Microbiota-induced type I interferons instruct a poised basal state of dendritic cells. Cell, 181:1080–1096.e19 Link

Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, and Bopp T (2018) Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages. Nat Immun, 19(12):1319–1329 Link

Ulges A, Witsch EJ, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, LuessiF, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F and Bopp T (2016) Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci USA, 113(36):10145–50 Link

Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E and Bopp T (2015) Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immun, 16(3):267–75 Link

Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E and Bopp T (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity, 33(2):192–202 Link