Martin Löwer

I am a computational immune-biologist focusing on the interaction of pathogens, diseased cells and the host immune system. My core expertise includes the computational modelling of the presentation of antigens derived from pathogens or genomic variants and their recognition by T-cell receptors, as well as the detection of genomic and transcriptomic variants from NGS data. Furthermore, I have experience in translating findings of basic biomedical research into clinical use.

TRON website

Positions held

• Since 2020: Deputy Director, Biomarker Development Center, Translational Oncology (TRON), University Medical Center, Johannes Gutenberg University, Mainz, Germany
• 2015 - 2020: Head of Bioinformatics, Translational Oncology (TRON), University Medical Center, Johannes Gutenberg University, Mainz, Germany
• 2010 - 2014: Computational Biologist, Translational Oncology (TRON), University Medical Center, Johannes Gutenberg University, Mainz, Germany
• 2009 - 2009: Freelance software developer, Merz Pharma GmbH, Frankfurt am Main, Germany
• 2007 - 2010: Research Assistant, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany

Education

• 2010: PhD in Bioinformatics, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany
• 2006: Diploma in Bioinformatics, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany

Selected publications by Martin Löwer

Schrörs B, Boegel S, Albrecht C, Bukur T, Bukur V, Holtsträter C, Ritzel C, Manninen K, Tadmor AD, Vormehr M, Sahin U and Löwer M (2020) Multi-omics characterization of the 4T1 murine mammary gland tumor model. Front Oncol, 10:1195 Link

Holtsträter C, Schrörs B, Bukur T and Löwer M (2020) Bioinformatics for cancer immunotherapy. In: Bioinformatics for Cancer Immunotherapy. Methods Mol Biol, vol 2120 (eds Boegel S), Humana, New York, NY Link

Hilf N, ...Löwer M, .... and Wick W (2019) Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature, 565:240-245 Link

Türeci Ö, Löwer M, Schrörs B, Lang M, Tadmor A and Sahin U (2018) Challenges towards the realization of individualized cancer vaccines. Nat Biomed Eng, 2:566–569 Link

Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Löwer M,... and Türeci Ö (2017) Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature, 547:222-226 Link