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Kristina Endres

Molecular Mechanisms of Neuronal Ageing

My group is interested in molecular pathways that interfere with physiological and pathological processes of neuronal ageing. We aim to elucide how resilient ageing can be achieved and why not only certain individuals but also certain brain regions seem to be more resilient towards the ageing process than others are. For these purposes, we use cellular and animal models of healthy ageing, accelerated ageing and diseased ageing (e.g. Alzheimer’s disease) and elucidate the mechanisms that transfer individuals from one state to the other (loss or gain of resilience). We apply proteomics, transcriptomics and functional assays, combined with pharmacological or microbial treatment (e.g. fecal material transfer). Another focus of our recent work is to evaluate quality of ageing and to correlate it to cognitive functions using frailty indexing or muscular parameters (sarcopenia).

Research website

Positions held

  • Since 2022: APL Professor, UMC, Johannes Gutenberg University (JGU), Mainz
  • Since 2009: Head of Laboratory, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University (JGU), Mainz
  • 2008 - 2014: Project Leader in NGFN consortium AD-IG 
  • 2005 - 2009: Research Associate, Institute of Biochemistry/ Institute of Therapeutic Life Sciences, Mainz


  • 2014: Habilitation in Biochemistry, Johannes Gutenberg University (JGU), Mainz
  • 2005: PhD in Biochemistry, Johannes Gutenberg University (JGU), Mainz
  • 2001: Diploma, Johannes Gutenberg University (JGU), Mainz
  • 1996 - 2001: Studies of Biology, Johannes Gutenberg University (JGU), Mainz

Selected publications by Kristina Endres

Nguyen VTT and Endres K (2022) Targeting gut microbiota to alleviate neuroinflammation in Alzheimer's disease. Adv Drug Deliv Rev, 188:114418 Link

Valeri F, Dos Santos Guilherme M, He F, Stoye NM, Schwiertz A and Endres K (2021) Impact of the age of cecal material transfer donors on Alzheimer's disease pathology in 5xFAD mice. Microorganisms, 9:2548 Link

Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K and Lichtenthaler SF (2019) NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. EMBO Mol Med, 11:e9695 Link

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A and Endres K (2017) Altered gut microbiome composition and tryptic activity of the 5xFAD Alzheimer's mouse model. J Alzheimers Dis, 56:775–788 Link

Schuck F, Wolf D, Fellgiebel A and Endres K (2016) Increase of α-Secretase ADAM10 in platelets along cognitively healthy aging. J Alzheimers Dis, 50:817-26 Link