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Kristina Endres

Molecular Mechanisms of Neuronal Ageing

My group is interested in molecular pathways that interfere with physiological and pathological processes of neuronal ageing. One of our aims is to elucidate how healthy ageing can be achieved, e.g. by using resilience mechanisms. Therefore, we analyse proteins that have been characterised as being longevity factors and/or to have neuro-protective properties and their potential interplay with gaining resilience.

Our research is also focused on molecular mechanisms of Alzheimer’s disease, one of the major neurological diseases of the elderly. One example of this is our investigation of the alpha-secretase ADAM10, which is capable of preventing the deposition of senile plaques in the brain. This enzyme has been shown to increase in cognitively healthy ageing, but is diminished in MCI (Mild cognitive impairment) or Alzheimer’s disease patients. We identified several regulators of ADAM10 using cellular screening approaches. Some of the "druggable" candidates have already been successfully transferred to pre-clinical animal studies and first studies in patients. A comparably new focus of our research is the interplay of healthy and diseased ageing in the gut-brain-axis. Within the last few years, we not only described an altered microbiome in a mouse model of Alzheimer’s disease, but also identified characteristics of enteric neurons that are impacted by Alzheimer's and ageing.

Research website

Positions held

  • Since 2009: Head of Laboratory, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University (JGU), Mainz
  • 2008 - 2014: Project leader in NGFN consortium AD-IG 
  • 2005 - 2009: Research Associate, Institute of Biochemistry/ Institute of Therapeutic Life Sciences, Mainz

Education

  • 2014: Habilitation in Biochemistry, Johannes Gutenberg University (JGU), Mainz
  • 2005: PhD in Biochemistry, Johannes Gutenberg University (JGU), Mainz
  • 2001: Diploma, Johannes Gutenberg University (JGU), Mainz
  • 2001: Studies of Biology, Johannes Gutenberg University (JGU), Mainz

Selected publications by Kristina Endres

Dos Santos Guilherme M, Todorov H, Osterhof C, Möllerke A , Cub K, Hankeln T, Gerber S and Endres K (2020) Impact of acute and chronic amyloid-β peptide exposure on gut microbial commensals in the mouse. Front Microbiol, 11:1008 Link

Stoye NM, Dos Santos Guilherme M and Endres K (2020) Alzheimer's disease in the gut-Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player. FASEB J, 34:11883–11899 Link

Hewel C, Kaiser J, Wierczeiko A, Linke J, Reinhardt C, Endres K# and Gerber S# (2019) Common miRNA patterns of Alzheimer's disease and Parkinson's disease and their putative impact on commensal gut microbiota. Front Neurosci, 13:113 (#indicates joint correspondence) Link

Endres K and Schäfer KH (2018) Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases. J Innate Immun, 10(3):172–180 Link

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A and Endres K (2017) Altered gut microbiome composition and tryptic activity of the 5xFAD Alzheimer's mouse model. J Alzheimers Dis, 56(2):775–788 Link