Skip to main content

Oliver Tüscher

Neurocognitive Mechanisms of Mental Resilience

Our research group uses modern methods of cognitive behavioural research (behavioural tests and ambulatory assessments) and neurophysiology (e.g. fMRI, DTI/VBM, EEG/fMRI, EEG, MEG, EEG/MEG, PET, and imaging genetics) to understand neurocognitive mechanisms of mental resilience in stress-related diseases. Thematic focuses include the systematic study of self-control as a resilience mechanism, in particular the cognitive domains of emotional regulation, impulse control, attention and social interaction, as well as the translational mechanisms of stress vaccination, taking into account interindividual differences and age. We also investigate hypotheses on neuronal oscillatory mechanisms and the effect of differences in network excitability on individual resilience.

Research website- Leibniz Institute for Resilience Research

Research website- University Medical Center, Mainz

Positions held

  • Since 2020: Research Group Leader and Head of Clinical Investigation Center (CIC), Leibniz Institute for Resilience Research (LIR), Mainz
  • Since 2016: W2 Professor of Clinical Resilience Research at the Dept. of Psychiatry and the German Resilience Center (DRZ), Johannes Gutenberg University (JGU), Mainz
  • Since 2015: Vice-chair, Dept. of Psychiatry, Johannes Gutenberg University (JGU), Mainz
  • Since 2013: Attending in Psychiatry and Psychotherapy
  • 2013: Board certification for Psychiatry and Psychotherapy 
  • 2010: Board certification for Neurology 
  • 2010 - 2013: Residency, Dept. of Psychiatry, Johannes Gutenberg University (JGU), Mainz
  • 2009 - 2010: Residency, Dept. of Psychiatry, University of Freiburg 
  • 2006 - 2010: Head, Emotion Regulation and Impulse Control Imaging Group (ERIC) at the Freiburg Brain Imaging, University of Freiburg 
  • 2006 - 2009: Residency, Dept. of Neurology, University of Freiburg 
  • 2003 - 2006: Postdoc and supervised consultant service, Div. of Neuropsychiatry, Dept. of Psychiatry, Weill Medical College Cornell University, New York
  • 2001 - 2003: Residency, Dept. of Neurology, UKE, University of Hamburg


  • 2011: Habilitation for Neurology, University of Freiburg 
  • 2002: MD/PhD studies within the DFG-Graduate program in Molecular and Cellular Neurobiology, University of Heidelberg 
  • 1995 - 2000: Medical School, University of Heidelberg
  • 1992 - 1995: Medical School, University of Bochum

Selected publications by Oliver Tüscher

Schaum M, Pinzuti E, Sebastian A, Lieb K, Fries P, Mobascher A, Jung P, Wibral M and Tüscher O (2021) Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans. Elife, 10:e61679 Link

Fischer FU, Wolf D, Tüscher O and Fellgiebel A (2021) Alzheimer’s Disease neuroimaging initiative. Structural network efficiency predicts resilience to cognitive decline in elderly at risk for Alzheimer's Disease. Front Aging Neurosci, 13:637002 Link

Gerlicher AVM, Tüscher O and Kalisch R (2018) Dopamine-dependent pre-frontal reactivations explain long-term benefit of fear extinction. Nat Commun, 9:4294 Link

Kalisch R, Müller MB and Tüscher O (2015) A conceptual frame-work for the neurobiological study of resilience. Behav Brain Sci, 38:e92 Link

Endres K, Fahrenholz F, Lotz J, Hiemke C, Teipel S, Lieb K, Tüscher O# and Fellgiebel A# (2014) Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin. Neurology, 83:1930–1935 (#indicates joint correspondence) Link